New selective PAD4 inhibitors binding a calcium-deficient form of the PAD4 enzyme have validated the critical enzymatic role of human and mouse PAD4 in both of those histone citrullination and neutrophil extracellular lure formation for, to our knowledge, the first time. The therapeutic opportunity of PAD4 inhibitors can now be https://courtneyo887bny0.ouyawiki.com/user