Pentobarbital will lower the extent or influence of ritonavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. pentobarbital decreases levels of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Potent CYP3A4 inducers can reduce panobinostat levels by ~70% and lead to therapy failure. Abrupt withdrawal of anti... https://crowfootk899sgv8.livebloggs.com/profile