Chemotherapy was potentiated by E7449 and one agent had substantial antitumor action in BRCA-deficient xenografts. Also, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell lines, probably by way of TNKS inhibition. In keeping with this risk, E7449 stabilized axin and TNKS proteins causing β-catenin de-stabilization and noticeably altered expression of https://sag-hydrochloride-91254531738.tribunablog.com/the-basic-principles-of-tussilagone-43744958