The impairment of HMGB1 functionality leads to elevated mitochondrial DNA harm. Inside the SCA1 mouse model, more than-expression in the HMGB1 protein via an introduced virus vector bearing the HMGB1 gene facilitates repair from the mitochondrial DNA harm, ameliorates the neuropathology and also the motor deficits, and extends the lifespan https://shikonin32109.blogpixi.com/28542578/fascination-about-313