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DNA ligases seal 5′-PO4 and three′-OH polynucleotide finishes through three nucleotidyl transfer steps involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are critical guardians of genomic integrity, and ligase dysfunction underlies human genetic disorder syndromes. Crystal structures of DNA ligases bound to nucleotide and nucleic acid substrates have illuminated how https://www-ligaz-bet04926.ageeksblog.com/27529057/5-tips-about-sports-betting-online-you-can-use-today

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